Development of interspecific hybrids of Mus.

نویسندگان

  • J D West
  • W I Frels
  • V E Papaioannou
  • J P Karr
  • V M Chapman
چکیده

Artificial insemination has been used to produce interspecific mouse hybrids. Mus musculus x Mus cervicolor cervicolor hybrids failed to complete more than a few cleavage divisions but both M. musculus x M. dunni and M. musculus x M. caroli hybrids completed preimplantation development. These hybrid embryos are heterozygous for various X-linked enzymes and may provide a useful genetic system for studying X-chromosome inactivation during early development. Further development of M. muscuius x M. caroli hybrids was studied: several completed foetal development; a few survived to maturity but none has yet reproduced.

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منابع مشابه

Genetic and developmental analysis of X-inactivation in interspecific hybrid mice suggests a role for the Y chromosome in placental dysplasia.

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عنوان ژورنال:
  • Journal of embryology and experimental morphology

دوره 41  شماره 

صفحات  -

تاریخ انتشار 1977